We study the development of color-sensing photoreceptors in the Drosophila eye as a model for the mechanisms that generate and maintain different types of sensory neurons. Remarkably, the distinction of the different photoreceptor subtypes involves conserved regulators that have been linked to human retinopathies and cancer. We recently discovered that a conserved set of four transcription factors specifies blue photoreceptors in flies and rod photoreceptors in mammals. Video: palindromes control gene expression Conserved transcription factors that specify photoreceptor subtypes
Moreover, we seek to elucidate how vitamin A deprivation and replacement therapy affect the structure and function of the retina, as well as its transcriptome, lipidome, and proteome (in collaboration with the Shevchenko lab, MPI Dresden). We also study the effects of vitamin A deficiency on the function of the mitochondria (in collaboration with Dr. Daisy Shu, Department of Ophthalmology, Harvard Medical School). This project has the potential to identify molecules and pathways that stabilize damaged photoreceptors and preserve visual function. Vitamin A deficiency in flies and mice
This research is supported by an R00/Pathway to Independence Award (R00EY023995) and an R01 grant (R01EY029659) from the NIH/NEI.
We also collaborate with the Hamad-Schifferli lab (Department of Engineering) to develop a nanoparticle-based drug delivery system to target drugs to the eye.
Lastly, we provide research experiences for students by participating in training programs such as the Research Experiences for Undergraduates (REU/NSF) and, in collaboration with the Dana-Farber/Harvard Cancer Center, the Summer Program to Advance Research Careers (SPARC) and the U54 partnership.